A novel study reveals that physical exercise can potentially lead to various alterations to many of the metabolites – which are small molecules produced by the body during metabolism – of the human body. According to the researchers, these changes made to the global metabolome – the entire group of metabolites present throughout the body, including the tissues, urine, and blood –might help them comprehend the body’s response to physical exercise in an improved way. The study, which was issued in the American Journal of Physiology, Endocrinology &Metabolism, has reportedly been selected as an APS select article for the month of November.
The human global metabolome, for the record, includes thousands of xenometabolites, which are basically ‘non-self’ chemicals that are the byproducts of organisms living in the gut microbiome (also known as the digestive tract) and also of the foods that the body consumes. According to Sean Adams, one of the corresponding authors of the study, a large number of the xenometabolites are known to affect health, in addition to enabling cross-talk, as well as signaling between the microbiome and the host.
The research team led by Adam carefully examined the global metabolome of sedentary women, which had obesity and insulin resistance both before and after exercise. The women were made to follow a reduced-calorie diet, along with an exercise regimen for up to fourteen weeks, which effectively resulted in weight loss as well as enhanced cardiovascular fitness. Furthermore, the researchers took blood samples of the women in every five minutes during the exercise sessions. However, Adams suggested that a more extensive research is require in order to understand the precise reason behind this process.
“Future studies should address the tissue‐specific origins of exercise‐related metabolite changes, how the metabolome responds across the entire spectrum of low‐to‐modest‐to‐high intensity exercise, which pathways and metabolites link to exertion and fatigue signaling and the potential interrelationships between exercise, fitness and the xenometabolites,”explained the researchers.